Editorial
Immunohistochemical study of progressive pulmonary tuberculosis
Abstract
About a quarter of the world’s population is infected with Mycobacterium tuberculosis. The study of new cellular and molecular mechanisms involved in the immune response to mycobacteria is necessary for the development of modern personalized patient treatment protocols
Original researches
Assessing the safety of chemotherapy for multidrug-resistant tuberculosis in patients with chronic viral infections
Abstract
The impact of chronic viral infections on the safety of complex treatment in patients with multidrug-resistant tuberculosis (MDR-TB) is poorly understood. The aim of the study was to evaluate the impact of chemotherapy of MDR-TB/HIV/HCV co-infections on the incidence of
Relative number of T and B cells in COVID-19 patients as a predictor of disease severity
Abstract
Severe COVID-19 with the possibility of death is usually associated with the development of a cytokine storm and is associated with severe lymphopenia. The aim of the study was to evaluate the dynamics of the relative number of lymphocytes (T and B cells) and their
Evaluation of the efficacy and safety of the drug Raphamin in the treatment of influenza in adults and children aged 12–18 years: analysis of the results of randomized clinical trials
Abstract
Influenza viruses cause seasonal epidemics, infecting about one billion people each year and resulting in hundreds of thousands of deaths. In addition to vaccination and direct-acting antiviral drugs, a promising approach is the use of agents that modulate the immune
The prognostic significance of cerebrospinal fluid laboratory parameters in bacterial meningitides
Abstract
Bacterial meningitis remains one of the leading causes of death from infectious diseases worldwide, with mortality rates varying from 4% to a range of 35–50%. A timely evaluation of the severity of this condition and an assessment of the risk associated with potential
Analysis of the epidemic process of HIV infection in a semiexclave region
Abstract
HIV infection remains one of the leading global health problems. The study of trends in the epidemic process of a multifactorial socially significant disease allows us to identify key aspects that determine the ups and downs of morbidity. The aim of the study is to determine
Frequency of detection of HBV and HCV infection markers in blood donors
Abstract
Hepatitis B and C viruses represent global health problems worldwide. Determination of markers of hepatitis B and C allows indirectly assessing the prevalence of hepatitis among the population. Objectives. The current study aimed to determine the markers of HBV and HCV among
Evaluation of herd immunity to tick-borne encephalitis virus in the Chelyabinsk region
Abstract
The aim of the study was to analyze herd immunity to tick-borne encephalitis virus among the population of the Chelyabinsk region. Material and methods. The study included the adult working-age population of 2 municipalities of the Chelyabinsk region located in different
Reviews
Influenza vaccination as a component to eliminate healthcare-associated infections
Abstract
Influenza vaccination plays a key role in the prevention of healthcare-associated infections (HAIs), especially during the seasonal increase in incidence. Despite the rise in influenza cases in 2023, epidemiological data show that vaccination effectively reduces both the
Triglyceride-glucose index as predictor of COVID-19 severity and mortality: a systematic review and meta analysis
Abstract
Insulin resistance (IR) is increasingly recognized as a pivotal risk factor for poorer clinical outcomes of coronavirus disease 2019 (COVID-19). The triglyceride-glucose (TyG) index has recently emerged as a dependable marker for assessing IR. Therefore, this study aimed to
Umifenovir (Arbidol) and acute rotavirus gastroenteritis: antiviral activity, mechanism of action, review and meta-analysis of clinical studies
Abstract
Acute viral gastroenteritis (AGE) remains a significant public health concern, especially among children under 5 years old, where it is a leading cause of hospitalization. Due to the lack of specific antiviral agents, the treatment of AGE is mainly symptomatic, with only a
Diagnostics of chronic lyme borreliosis involving the musculosketal system (material for preparing the lecture)
Abstract
Confirming the diagnosis of tick-borne borreliosis often causes difficulties even in the acute phase of infection. In case of chronic Lyme borreliosis, the interpretation of clinical, anamnestic, laboratory and instrumental data is especially difficult. In some cases, Lyme
Continuing medical education
Legal problems of vaccination of employees
Abstract
Vaccination of workers is an important measure in the system of ensuring public health and epidemiological safety of citizens. The employer is required by law to implement measures for the sanitary and epidemiological welfare of the population, including vaccination. The
Practitioner’s consult
Measles problems: a clinical case of measles meningoencephalitis in a teenager
Abstract
The measles situation worldwide has been tense for over two years. According to the World Health Organization (WHO), in the twelve-month period from 2023 to 2024, there were 73,711 reported cases of disease in the European region, with 14 fatalities. In Russia, the incidence
Tick-borne encephalitis: clinical, epidemiological, pathogenetic and preventive aspects of the problem
Abstract
Tick-borne encephalitis remains an important international problem, with natural foci found in 26 countries around the world. The aim of the study is to assess the epidemic situation of tick-borne encephalitis in the Chelyabinsk region with an analysis of the biological
A case of imported Chikungunya fever
Abstract
The article presents a clinical case of Chikungunya virus disease in a 38-year-old patient. The peculiarity of this case is the late diagnosis of Chikungunya fever with severe clinical symptoms in a tourist who arrived from an endemic area (Thailand). The diagnosis upon
Experience in using antiviral drug riamilovir in a patient with epidemic parotitis
Abstract
A clinical case of parotitis infection with moderate damage to the pancreas and genitals in a 26-year-old man is considered. The diagnosis was confirmed by serological research. No etiotropic drugs with proven efficacy against the pathogen have been registered. In this
Clinical tests
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