Clinical case of a rare form of meningococcal infection in a young child
AbstractThe article presents a clinical description of a case of generalized meningococcal infection – meningoencephalitis, combined with a rare form of meningococcal infection – arthritis of the knee joint. As a result of the disease, the child lost his hearing.
The peculiarity of the case is isolated meningoencephalitis, without meningococcemia, which is the last in frequency among generalized forms of meningococcal infection. Arthritis, according to the classification, is a rare form of meningococcal infection. This is the first case of generalized meningococcal infection caused by Neisseria meningitidis serogroup W in the Republic of Sakha (Yakutia).
Keywords: meningococcal infection; meningoencephalitis; arthritis; bilateral deafness
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
Contribution. The authors contributed equally to this article.
For citation: Dmitrieva T.G., Kozhuhova Zh.V., Agaeva L.Z. Clinical case of a rare form of meningococcal infection in a young child. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2025; 14 (1): 103–7. DOI: https://doi.org/10.33029/2305-3496-2025-14-1-103-107 (in Russian)
References
- State report «On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2023». Moscow, 2024. URL: https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=27779&ysclid=m486ranwsw278297753 (in Russian)
- Lobzin Yu.V., Ivanova M.V., Skripchenko N.V., Vil’nits A.A., Karev V.E., Gorelik E.Yu., et al. Clinical and epidemiological peculiarities of the general meningococcal infection and new opportunities of therapy. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2018; 7 (1): 69–77. DOI: https://doi.org/10.24411/2305-3496-2018-00009 (in Russian)
- Koroleva M.A., Gritsay M.I., Koroleva I.S., Akimkin V.G., Mel’nikova A.A. Purulent bacterial meningitis in the Russian Federation: Epidemiology and Immunization. Zdorov’e naseleniya i sreda obitaniya [Public Health and Life Environment]. 2022; 30 (12): 73–80. DOI: https://doi.org/10.35627/2022-30-12-73-80 (in Russian)
- Gryntsevich L.V., Liopo T.V., Sokolova T.N. Epidemiology of meningococcal infection in the Grodno region in 2018–2022. Zhurnal Grodnenskogo gosudarstvennovo meditsinskogo universiteta [Journal of Grodno State Medical University]. 2023; 21 (4): 400–5. (in Russian)
- Clinical guidelines «Meningococcal infection in children». URL: https://cr.minzdrav.gov.ru/schema/58_2 (in Russian)
- Banadyga N.V. Rare forms of meningococcal infection in children (clinical observations). Zdorov’e rebenka [Child’s Health]. 2013; 50 (7): 157–61. (in Ukrainian)
- Davydova I.V., Smirnova T.Yu., Litvinova O.G., Partilkhaeva I.Ch. A case of meningococcal pneumonia complicated by bilateral pleurisy, pericarditis. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2022; 11 (4): 127–33. (in Russian)
- Feldman C., Anderson R. Meningococcal pneumonia: a review. Pneumonia (Nathan). 2019; 11: 3. DOI: https://doi.org/10.1186/s41479-019-0062-0
- Winstead J.M., McKinsey D.S., Tasker S., De Groote M.A., Baddour L.M. Meningococcal pneumonia: characterization and review of cases seen over the past 25 years. Clin Infect Dis. 2000; 30 (1): 87–94. DOI: https://doi.org/10.1086/313617
- Mazankova L.N., Samitova E.R., Khoroid N.V., Ermakova M.N., Cheburkin A.A. Rare generalized form of meningococcal disease caused by Neisseria meningitidis serogroup W. Zhurnal infektologii [Journal of Infectology]. 2020; 12 (1): 111–8. DOI: https://doi.org/10.22625/2072-6732-2020-12-1-11-118 (in Russian)
- Hellum M., Ovstebo R., Brusletto B.S., et al. Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock. Thromb Res. 2014; 133: 507–14.
- Ladharri S.N., Beebeejaun К., Lucidarme L., et al. Increasein endemic Neisseria meningitidis capsular group W sequence type 11 complex associated with severe invasive disease in England and Wales. Clin Infect Dis. 2015; 60 (4): 578–85.
- Bethea J., Makki S., Gray S., MacGregor V., Ladhani S. Clinical characteristics and public health management of invasive meningococcal group W disease in the East Midlands region of England, United Kingdom, 2011 to 2013. Euro Surveill 2016; 21 (24). DOI: https://doi.org/10.2807/1560-7917.ES.2016.21.24.30259
- Knol M., Ruijs W.L.M., Melker H.E., Berbers G.A.M., van der Ende A. Plotselinge toename van invasieve meningokokkenziekte serogroep W in 2015 en 2016. Infectieziekten Bulletin. 2017; 28 (1): 23–8.
- Abad R., Vázquez J.A. Early evidence of expanding W ST-11 CC meningococcal incidence in Spain. J Infect. 2016; 73 (3): 296–7. DOI: https://doi.org/10.1016/j.jinf.2016.06.010
- Bratcher H.B., Corton C., Jolley K.A., Parkhill J., Maiden M.C. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014; 15: 1138. DOI: https://doi.org/10.1186/1471-2164-15-1138
- Issa M., Mölling P., Unemo M., Bäckman A., Mosaad M., Sulaiman N., et al. Neisseria meningitidis serogroup W-135 isolated from healthy carriers and patients in Sudan after the Hajj in 2000 Scand. J Infect Dis. 2003; 35 (4): 230.
- Popovic T., Sacchi C.T., Reeves M.W., Whitney A.M., Mayer L.W., Noble C.A., et al. Neisseria meningitidis serogroup W135 isolates associated with the ET-37 complex. Emerg Infect Dis. 2000; 6 (4): 428–9.
- Aguilera J.F., Perrocheau A., Meffre C., Hahné S. Outbreak of serogroup W135 meningococcal disease after the Hajj pilgrimage, Europe, 2000. Emerg Infect Dis. 2002; 8: 761–7.
- Sadarangani M., Scheifele D.W., Halperin S.A., Vaudry W., Le Saux N., Tsang R., et al.; Investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT). Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study. Clin Infect Dis. 2015; 60 (8): e27–35. DOI: https://doi.org/10.1093/cid/civ028 PMID: 25605282.