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1 . 2025
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Features of the clinical course of pneumonia caused by carbapenem-resistant strains of Klebsiella pneumoniae, resistant and sensitive to antibiotic combinations

Abstract

The purpose. To compare clinical and laboratory parameters and outcomes of pneumonia caused by carbapenem-resistant strains of Klebsiella pneumoniae depending on their sensitivity to antibiotic combinations.

Material and methods. A retrospective case-control study was conducted. The main group consisted of 25 people with pneumonia caused by K. pneumoniae with resistance to the combination of meropenem/amikacin/colistin, the control group – 25 patients with pathogen sensitivity to this combination. Clinical and laboratory data, concomitant diseases, treatment regimens, and disease outcomes were analyzed. Statistical processing of the obtained data was carried out using the Statistica 12.5 software package.

Results and discussion. Pneumonia caused by carbapenem-resistant strains of K. pneumoniae with resistance to the combination of meropenem/amikacin/colistin was characterized by more severe course, a high proportion of patients treated in the intensive care unit, and a higher risk of death.

Conclusion. The results of the study have practical significance in assessing the severity of the condition of a patient with K. pneumonia, indications for timely transfer to intensive care units and correction of antibacterial therapy.

Keywords: pneumonia; Klebsiella pneumonia; antibiotic resistance; carbapenem resistance

Funding. The work was financially supported by the Belarusian Republican Foundation for Fundamental Research (grant No. M23M-106).

Conflict of interest. The authors declare no conflict of interest.

Contribution. Conducting the study – Levchenko K.V.; collection of material – Levchenko K.V., Karpova E.V., Chmyhova I.A.; development of study design, data processing – Levchenko K.V., Mitsura V.M., Tapalski D.V.; writing the text – Levchenko K.V., Mitsura V.M.; text editing – Levchenko K.V., Mitsura V.M., Tapalski D.V., Bondarenko V.N., Karpova E.V. All authors confirm that their authorship meets the international ICMJE criteria (all authors made a significant contribution to the development of the concept, conduct of the study and preparation of the article, read and approved the final version before publication).

For citation: Levchenko K.V., Mitsura V.M., Tapalski D.V., Karpova E.V., Bondarenko V.N., Chmyhova I.A. Features of the clinical course of pneumonia caused by carbapenem-resistant strains of Klebsiella pneumoniae, resistant and sensitive to antibiotic combinations. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2025; 14 (1): 48–54. DOI: https://doi.org/10.33029/2305-3496-2025-14-1-48-54 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)
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