The influence of spacial and temporal factors for genetic evolution of filoviruses

• Gennadiy G. Onishchenko
• Tatyana E. Sizikova
• Alexander A. Petrov
• Vitaliy N. Lebedev
• Sergey V. Borisevich

Abstract

The influence of special and temporal factors for genetic evolution of filoviruses is conducted.

With taking into consideration likely origin of all filoviruses from common ancestor, different level of pathogenicity of this agents may be consequence of its evolutionary change. The evolutionary change of virus depends upon its hosts, the widest range of natural hosts and region of its spreading, the higher of evolutions rate.

The time of divergence from common ancestor, numbers of nucleotide exchanges for this time, rate of evolution are determined for different filoviruses based on results of molecular-genetic analyze received by a number of authors.

The age of Filoviridae family is 10 400 years, the range of evolutions rate for different kinds of filoviruses is from 0.46×10^-4 (for Ebola-Zaire virus) to 8.21×10^-4 nucleotide exchanges per year (for Ebola-Reston virus).

The influence of special and temporal factors on molecular evolution of Ebola-Zaire virus in time of epidemic in West Africa in 2013–2016 is conducted. The absence of alteration of evolutionary rate of Ebola virus in epidemic and no epidemic periods is ascertained.

Keywords: filoviruses; Marburg virus; Ebola virus; genome; evolutionary rate; nucleotide exchanges; phylogenetic analyze; Bayesian method

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